Ten DEGs, including IGF1, VEGFC, RAPGEF3, PIK3CA, Akt3, ITGB3, ITGA11, SPP1, NOS1, and ATP6V0B, were selected from Rap1, oxidative phosphorylation, and Alzheimer’s disease signaling pathways. The gene discussed is NOS1; the disease is early-onset autosomal dominant Alzheimer disease.