Ten DEGs, including IGF1, VEGFC, RAPGEF3, PIK3CA, Akt3, ITGB3, ITGA11, SPP1, NOS1, and ATP6V0B, were selected from Rap1, oxidative phosphorylation, and Alzheimer’s disease signaling pathways. This evidence concerns the gene SPP1 and early-onset autosomal dominant Alzheimer disease.