Other non-neuronal roles attributed to NRF1 are the regulation of oncogenesis [40,41,42,43], stem cell aging [44], telomere transcription [45] and oxidative stress protection and lipid homeostasis in the liver; liver-specific Nrf1 conditional knockout mice develop steatohepatitis and spontaneous liver cancer [43]. The gene discussed is NRF1; the disease is liver cancer.