Wounding studies in Lgr6EGFP-IRES-CreERT2 mice have shown the contribution of Lgr6-expressing cells to long-term maintenance of HFs; however, Lgr6 is not exclusively expressed in the basal layer of the IFE and INF, but also in the HF junctional zone and SG (Füllgrabe et al., 2015; Kretzschmar et al, 2014, 2016; Page et al., 2013; Snippert et al., 2010). The gene discussed is LGR6; the disease is Hand-foot syndrome.