In addition, colonic CD11b+lamina propria mononuclear cells from Nfil3−/− mice spontaneously express Il‐12b mRNA and lower expression of NFIL3 was observed in CD14+lamina propria mononuclear cells from inflammatory bowel disease (IBD) patients compared with control subjects independently of the Il‐12b regulator [75] IL‐10 cytokine. This evidence concerns the gene NFIL3 and inflammatory bowel disease.