FAM111B and cancer: The herein highlighted chromosomal instability represents a hallmark that definitelylinks POIKTMP to cancer-predisposing syndromes driven by disruption of the mechanismssafeguarding genomic stability (Taylor etal., 2019), particularly Rothmund-Thomson type II syndrome wherepatients cells show centromere mis-division (Larizzaet al., 2006) and fragile telomeric ends (Ghosh et al., 2012), andDyskeratosis Congenita (DK) characterized by short telomeres (Savage, 2018).