Since B cells or DCs participate actively in allergy [29,30] and could contribute to downmodulation of Th2 immunity by the induction of B or T regulatory cells-producing IL-10 [31,32], we first determined whether MyD88 expression on these cells is required for the CpG-ODN-induced IL-10 production and consequent anti-allergic effect. The gene discussed is MYD88; the disease is allergic disease.