They showed that responder mice had increased infiltration of immune cells in the tumor microenvironment and augmented expansion of CD4+ and CD8+ memory cells (CD44+) in peripheral blood, yet also showed downregulation of regulatory cells (MDSCs and CD4+ Foxp3+ Tregs) or exhausted T cells (CD4+ PD1+ and CD8+ PD1+ T cells) [157]. The gene discussed is CD8A; the disease is neoplasm.