Therefore, this study aimed to design and evaluate the effect of the newly synthesized conjugates of previously investigated OAO derivatives with DCL (Figure 1) on Nrf2 and NF-κB signaling in connection with cell cycle distribution, apoptosis, and proliferation in normal hepatocytes, and HCC cell line and tumor growth in vivo. Here, NFKB1 is linked to hepatocellular carcinoma.