Notably, one cluster showed a strong positive association with neutropenia, granulocytopenia, agranulocytosis, neutropenic sepsis, neutropenic colitis, neutropenic infection, and febrile neutropenia, whereas the other, comprising protein kinase inhibitors and monoclonal antibodies (excluding the antimetabolite methotrexate), was less associated with CIN. This evidence concerns the gene WEE1 and Decreased total granulocyte count.