Another SMO antagonist, saridegib, was tested in combination with 5-fluorouracil, leucovorin, irinotecan, and oxaliplatin (FOLFIRINOX) in a phase I trial, and in addition to gemcitabine in a phase II trial, both conducted on previously untreated, advanced PC patients [84,85]. The gene discussed is SMO; the disease is pachyonychia congenita.