ERBB2 and neoplasm: HER2 was shown to be resistant to internalization in several tumor cell lines (SKBR3 [170,171,172,173,174,175,176], MDAMB-134 [177], T47D [178], BT474 [173], and HEp2 [176]) and models (HER2-transfected PAE cells, [173] and murine fibroblasts [177], and 3T3 [179] cells).