BCL2L1 and cancer: Additionally, aptamer-functionalized dendrimers shown high transfection efficiency, low cytotoxicity and Bcl-xL selective inhibition of cancer cells [91] For instance, AS1411-conjugated modified polyamidoamine (PAMAM) dendrimers efficiently target NCL positive cells (A549 cells), knockdown the protein expression of Bcl-xL and induce apoptosis in cancer cells (Figure 8) [91].