Due to the multifaceted pathogenesis of depression, this study aimed to clarify whether the KBD formula ameliorated the effect of UCMS-induced changes in expression levels of the depression-related genes BDNF, CREB, GR, SGK1, FKBP5, IL-1β, IL-6, and TNF-α. This evidence concerns the gene NR3C1 and major depressive disorder.