The KBD formula normalized UMCS-induced anhedonia and hopeless behaviors in mice by restoring expression of the depression-related genes BDNF, CREB, GR, SGK1, FKBP5, IL-1β, IL-6, and TNF-α in the frontal cortex and hippocampus brain regions. This evidence concerns the gene FKBP5 and major depressive disorder.