Given the 30,805 genes expressed in zebrafish, 733 genes were differentially expressed (FDR <0.05, |log2FC|>1) by excess insulin treatment and the results are presented as a heat map in Figure 9A. Among these 733 genes, 131 were up-regulated and 602 genes were downregulated by insulin resistance (Figure 9B). This evidence concerns the gene INS and Insulin resistance.