Patients suffering from RAEB and RAEB-T (5–20% abnormal blasts in bone marrow) [85] embodied increased risk of consisting hypermethylated regions in p15INK4b than patients with RA and RARS (<5% abnormal blasts in bone marrow) due to the apparent differences in disease progression and developed bone marrow blasts. The gene discussed is CDKN2B; the disease is myelodysplastic syndrome with excess blasts.