TET2 and acute myeloid leukemia: Somatic mutations of genes that encode epigenetic, transcription factors and signaling proteins in AML patients [11], include DNA methyltransferase 3A (DNMT3A), Ten-Eleven Translocation 2 (TET2), CCAAT Enhancer Binding Protein α (CEPBA), p53 and tyrosine kinase receptors [7].