TNF and infection: The nuclear translocation of the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) was elevated in the second week, coinciding with a significant increase in TNF-α during the first four weeks, which could suggest an inflammatory period of sporotrichosis, while higher levels of IL-10 production were observed in the final stages of the study, suggesting its possible role as an inhibitor of TNF-α secretion and, therefore, as an anti-inflammatory cytokine during infection.