TNF and skin infection: The CD206high/M2-like dermal resident macrophages could play an important role in all evolution stages of experimental skin infection with S. schenckii because the MR has already been involved in the binding and phagocytosis of opsonized conidia [86], without the release of TNF-α, while conversely releasing TNF-α and producing ROS induced by phagocytosis of opsonized and non-opsonized yeast.