Evidence for the participation of necroptosis during the onset and development of MCMV retinitis during MAIDS has been provided by the detection of significant amounts of necroptosis-associated receptor-interacting protein kinase 1 (RIPK1) and RIPK3 (Table 1) mRNAs within the MCMV-infected eyes of retinitis-susceptible mice with MAIDS at different times during retinitis development [43]. The gene discussed is RIPK3; the disease is retinitis.