Sinonasal epithelium shows high rates of double positive ACE2 and TMPRSS2 expressing cells [23] which, given that nasopharyngeal swabs have become the gold standard for COVID-19 testing [28], highlights the importance of the sinonasal mucosa as both an portal for SARS-CoV-2 infection and replication in human hosts. The gene discussed is TMPRSS2; the disease is COVID-19.