PTX3 and infection: Second, we focused on the early phases of the SA infection (that are relevant to bacterial adhesion and biofilm formation [3,41]), and observed different kinetics (between 2D and 3D) for the expression of inflammatory and antioxidant genes (Figure 6), with major regard to the long pentraxin PTX3, a well-established PRM with emerging roles in bone physiology and pathology [18,42].