A series of studies of fraxetin on hepatic damage induced by carbon tetrachloride or ethanol revealed that fraxetin significantly increased the levels of anti-oxidant enzymes such as catalase, superoxide dismutase, and glutathione peroxidase and decreased inflammatory mediators such as tumor necrosis factor α and interleukin 1β to prevent hepatic fibrosis [16,22]. The gene discussed is CAT; the disease is Hepatic fibrosis.