In the literature, the most common genes related to the development of melanomas in dogs are dependent on location: PTEN (mucosal) [11,33,34], TP53 (mucosal, skin) [33,34], KIT (skin) [33], BRAF (skin) [35] as well as NRAS and KRAS (mucosal, skin, digit) [11,33,34]. The gene discussed is PTEN; the disease is melanoma.