KLK3 and tuberculosis: Schoots et al24, suggest that MRI-targeted biopsies can be used in two different diagnostic pathways: the ‘combined pathway’, in which patients with a positive mpMRI undergo both systematic and targeted biopsy (TB) and patients with a prostate-specific antigen (PSA) density >0.15 ng ml−1/cc and a negative mpMRI undergo SB; and the “MRI pathway”, in which patients with a positive mpMRI undergo only MRI-TB, and patients with a negative mpMRI avoid biopsy.