It was previously reported that, although each leukocyte subpopulation is generally able to exhibit a cholinergic phenotype, mainly monocytes/macrophages increased theirs during sepsis and that AChE is mainly located within large cells of the red pulp, indicating that this enzyme is not located on leukocytes, but rather on megakaryocytes (Hoover et al. 2020). The gene discussed is ACHE; the disease is Sepsis.