Among patients with variations associated with CHIP (DNMT3A, TET2, ASXL1, JAK2), thrombosis occurred in 5 patients (62%; odds ratio [OR], 5.6; 95% CI, 1.3-15.9) and death in 3 patients (37%; OR, 6.1; 95% CI, 1.3-26.9). The gene discussed is JAK2; the disease is deep vein thrombosis.