Effectively, the latter authors previously demonstrated the presence of phosphorylated TDP-43-positive (FUS-negative) aggregates in myofibers of ALS patients, which were also positive for the autophagy pathway SQSTM1/p62, suggesting the possible implication of endogenous autophagic mechanisms in ALS muscles [174]. The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.