TARDBP and amyotrophic lateral sclerosis: Indeed, protein aggregates with TDP-43 [142,143], neurofilament [144], FUS [145], or SOD1 [146], which are detected in the vast majority of ALS patients, can appear in the cytoplasm of neurons [147] and within the skeletal muscle [148,149], suggesting an imbalance between protein synthesis and degradation pathways.