C9orf72 and amyotrophic lateral sclerosis: Besides, C9ORF72 mutations can interfere with the autophagy pathway at several levels (reviewed by [97]), and in particular, DPR proteins have been found not to be limited to neurons but also been detected in Sertoli cells [170], ependymal cells [171], and in the skeletal muscle of a zebrafish C9orf72 model [172], Drosophila C9orf72 model [173], and ALS patients [162].