This test is based on the expression patterns of eight proteins (DERL1, CUL2, SMAD4, PDSS2, HSPA9, FUS, pS6 and YBOX1) with known functions related to proliferation, tumour-associated signalling pathways and stress response, altogether providing information about tumour aggressiveness from formalin-fixed, paraffin-embedded (FFPE) tissues [276]. The gene discussed is SMAD4; the disease is neoplasm.