Additionally, over-expression of regulators, such as epidermal growth factor receptor (EGFR), protein kinases, such as Akt, or when the mutations occur, are reported to be correlated to tumor metastasis and invasion, with the production of matrix metalloproteinase 2 and degradation of collagen type IV (Figure 3) [21,22,23,24]. Here, EGFR is linked to neoplasm.