While CaSR autoantibodies may play a limited role, it is possible that the association of CaSR mutants with deficiency in humoral immunity may at least in part be related to diminished activation of NLRP3 inflammasome/IL-1β pathway and anti-tumor immune responses due to decreased sensitivity of the mutant CaSR at rs1801725 to calcium. The gene discussed is CASR; the disease is neoplasm.