CLIC1 and neoplasm: CLIC1 expression is correlated to a poor prognosis not only in pancreatic cancer, but also in tumors as lung cancer [36], ovarian cancer, where CLIC1 upregulation was correlated to chemotherapy resistance [37], gallbladder, and gastric cancers [38], where it was found to promote cells proliferation via MAPK/AKT regulation [39] and facilitates the formation of tumor-associated fibroblasts [40].