To evaluate the role of DAB1 germline mutations in pancreatic carcinoma/melanoma-prone families and their function with regard to a predisposition to FPC, Sanger sequencing of DNA obtained from the blood of an additional 31 PCMS index patients with either PDAC or malignant melanoma enrolled in the FaPaCa registry was performed. The gene discussed is DAB1; the disease is exocrine pancreatic carcinoma.