A new finding of the present study is that affected patients from one FPC family can carry identical germline variants in up to three different genes, e.g., DAB1, POLQ and FGFBP3 in family 25-9-44 or MAPK3 and ACAD9 in family 25-4-46, which segregate with pancreatic disease. Here, FGFBP3 is linked to pancreas disorder.