To further elucidate the role of endogenous BMP7 upregulation in glioma malignancy, human LN18 and LN229 glioblastoma cells were transfected with control- or BMP7-specific siRNA and incubated for 48 h and then the transmigration and migration capabilities of both glioblastoma cells were determined by the transwell and wound-healing assay, respectively. This evidence concerns the gene BMP7 and central nervous system cancer.