Overexpression of the YAP has been confirmed in numerous types of cancer and is associated with excessive cell proliferation, evasion of apoptosis, and tissue invasion, so targeting the YAP, its translocation to the cell nucleus and YAP-TEAD complexes, seems to be a reasonable therapeutic approach in treating tumors with YAP hyperactivation [8,9,10,11,12]. The gene discussed is YAP1; the disease is cancer.