YAP1 and skin squamous cell carcinoma: Debaugnies et al. [29] and Sambandam et al. [42] demonstrated, on a murine model, that the YAP is necessary for SCC cell initiation and cell proliferation, while genome-wide screening revealed that the YAP drives clonal cell expansion by the TEAD-dependent transcription of survival-promoting genes in both healthy skin and cSCC [43], which suggests the vital role of the YAP/Hippo pathway in cSCC.