Although it has been revealed that silencing the YAP decreases the invasive ability of cSCC cells and results in decreased expression matrix metalloproteinases involved in tumor metastasis, e.g., MMP-2 and MMP-9 [48], it has still not been elucidated how YAP/Hippo signaling controls ECM homeostasis in cSCC. The gene discussed is YAP1; the disease is neoplasm.