Quan et al. [28] reported that in normal adult human skin the YAP is predominantly expressed within the cytoplasm of epidermal keratinocytes in the interfollicular epidermis and outer sheath of the hair follicles, while, in BCC, the expression of the YAP was found in the tumor island cells both in the cytoplasm and nuclei with 10-fold greater protein levels in BCC tumor islands than in normal epidermis [28] indicating atypical YAP regulation in BCC. This evidence concerns the gene YAP1 and neoplasm.