Jia et al. [48] showed that the YAP is expressed within cells, parakeratotic columns in AK (45.2% of YAP-positive staining), and atypical epidermal cells (70.6% of YAP-positive staining) in BD indicating the possible Hippo pathway involvement in precancerous lesion formation [48]. This evidence concerns the gene YAP1 and Behcet disease.