Several angiogenesis-related molecules (vascular endothelial growth factor and soluble vascular endothelial growth factor receptor 1, but not soluble vascular endothelial growth factor receptor 2, angiopoietin-1 or angiopoietin-2) were detected in elevated levels in ET subjects, whereas controls had higher placenta growth factor levels [40]. This evidence concerns the gene KDR and essential thrombocythemia.