The FVIIa/AT complex concentrations in the plasma were also elevated in ET versus controls (p < 0.01), but the JAK2 V617F mutation seems to play a key role in this finding, as only JAK2 V617F-positive cases seemed to display higher levels of FVIIa/AT complex in the plasma versus controls (p < 0.05) [32]. The gene discussed is JAK2; the disease is essential thrombocythemia.