The median levels of DKK-1 (4625 pg/mL), IL-6 (11.7 pg/mL), and IL-8 (20 pg/mL) in the mCRPC patients were higher than those in the PCa-l patients (3939 pg/mL, 5.6 pg/mL, and 10.8 pg/mL, respectively). This evidence concerns the gene DKK1 and posterior cortical atrophy.