The aim of our preliminary study was to investigate the association of an elevated CTC count with inflammatory molecules (IL-6 and IL-8) and biomarkers (DKK-1, sHER2, and CD44) in patients with metastasized CPRC (mCPRC) under chemotherapy and localized PCa (PCa-l). Here, CXCL8 is linked to posterior cortical atrophy.