CTSE and neoplasm: At the univariate level, CTSE overexpression in tumor specimens was an unfavorable prognostic factor for all three endpoints: disease-specific survival (DSS), metastasis-free survival (MeFS) (both p < 0.0001), and local recurrence-free survival (LRFS) (p = 0.0001) (Table 3 and Figure 3).