Grade and the presence of metastasis are important prognostic factors in CRC, and in our analysis based on the PrognoScan data, RIPK2 expression was associated neither with grade (p = 0.09) nor with the presence of metastasis (p = 0.25), but it was associated with long-term survival (p < 0.01). Here, RIPK2 is linked to colorectal carcinoma.