TP53 and colorectal carcinoma: These proteins also play a role in the survival and prognosis of CRC patients, where high MKI67 expression is correlated with decreased overall survival and disease-free survival, TP53 expression was found to be significantly associated with poor survival, and VEGF expression was associated with decreased survival, higher grade, presence of lymph node metastasis, depth of invasion, and overall stage [23,24,25,26,27,28].