RIPK2 and cancer: However, some studies showed that RIPK2 plays a role in metastasis in different cancer forms; for example, in TNBC, RIPK2 knockdown decreases migration and lung metastasis, in inflammatory breast cancer, higher RIPK2 activity was correlated with metastasis, and in hepatic cell carcinoma, knockdown of RIPK2 downregulated multiple genes involved in epithelial–mesenchymal transition [12,14,36].