CD4 and histoplasmosis: In this series, the HIV patients with disseminated histoplasmosis (i.e., more than one infection site) had a CD4 count of <200 cells/mm3, extracellular H. capsulatum, >50 yeasts per hot spot, and either cluster pattern II (cluster or chain of >5 yeasts) or III (rosette > 10 yeasts).