GPI and autoimmune polyendocrinopathy: According to the guidelines issued by the International Society on Thrombosis and Haemostasis (ISTH), APS is defined whenever there is the coexistence within the same patient of at least one clinical event (i.e., venous/arterial thrombosis or pregnancy complications) and positivity for LA or the presence of medium-high titers of either aCL or aβ2-GP-I [2].