According to guidelines, clinicians should also be informed that the laboratory diagnosis (if positive) must be confirmed 12 weeks apart as LA positivity in some patients may be transient and is not of clinical significance [7] Finally, results should be interpreted, validated, and reported in combination with the other APS parameters (i.e., aCL and a β2-GP-I), keeping in mind that triple positivity identify patients at high risk. The gene discussed is APOH; the disease is autoimmune polyendocrinopathy.