LDLR and familial hypercholesterolemia: PSCK9 has been positively associated with cIMT, independently of traditional VRFs, in relatively small studies carried out in specific cohorts, including healthy individuals (n = 120) [15], newly diagnosed type 2 diabetes mellitus participants (n = 100) [16], systemic sclerosis patients (n = 73) [17], hypertensive subjects (n = 126) [18], and first-degree relatives of patients with familial hypercholesterolemia who were negative for the familial LDL-R or APOB mutation (n = 112) [19].