PLA2G6 and neurodegeneration with brain iron accumulation 2A: Recessive mutations in PLA2G6 were found to induce alterations in phospholipid metabolism and abnormal iron accumulation, which ultimately led to infantile neuroaxonal dystrophy (INAD), atypical neuroaxonal dystrophy (ANAD) and neurodegeneration with brain iron accumulation (NBIA).