Heterozygous familial hypercholesterolemia (HeFH), the most frequent human metabolism monogenic disorder caused by mutations in the genes encoding for the low-density lipoprotein (LDL) receptor [1], apolipoprotein (Apo) B-100 [2], proprotein convertase subtilisin/kexin-type 9 (PCSK9) [3] or Apo E [4], entails high LDL cholesterol concentrations, resulting in a high lifetime risk for cardiovascular disease (CVD). Here, PCSK9 is linked to cardiovascular disorder.