HOTTIP and amyotrophic lateral sclerosis: For these reasons, we decided to investigate the deregulated expression of a panel of lncRNAs (linc-Enc1, linc–Brn1a, linc–Brn1b, linc-p21, Hottip, Tug1, Eldrr, and Fendrr) implicated in neural stem cells differentiation and oncogenesis [14,15,16,17,18,19,20,21,22,23,24,25,26,30], in a murine familial model of ALS (the SOD1-G93A mouse) at a pre-symptomatic and symptomatic stage of the disease.