To this end, the aim of this work was to investigate a panel of lncRNAs (linc-Enc1, linc–Brn1a, linc–Brn1b, linc-p21, Hottip, Tug1, Eldrr, and Fendrr) implicated in both murine development and oncogenesis, in a murine familial model of ALS (the SOD1-G93A mouse). The gene discussed is TUG1; the disease is amyotrophic lateral sclerosis.