HOTTIP and central nervous system cancer: The lncRNAs all presented a trend of downregulation, and especially significant are the down-regulations present in HOTTIP and ELDRR. The expression deregulation is opposite to that observed in tumors for PANTR1 and HOTTIP, as PANTR1 is upregulated in glioma and nasopharyngeal carcinoma and HOTTIP was found upregulated in oral tongue squamous cell carcinoma and gastric cancer [24,25].