PCSK9 is thought to play an important role in cardiovascular diseases (CVDs) via different mechanisms, either through binding to Epidermal Growth Factor (EGF) domains on receptors or through binding with receptors present in lipid rafts and associated cell membrane micro-domains or by influencing the gene expression and protein response of various factors involved in the development of cardiac complications [18]. This evidence concerns the gene PCSK9 and cardiovascular disorder.