BIRC5 and glioblastoma: However, the reduction of luciferase activity was not observed in the GBM cells transfected with BIRC5-Mut plasmids (GBM12, p = 0.02; GBM28, p = 0.94; and GBM43, p = 0.92) (Figure 4C), indicating that the direct interaction between miR-138 and the 3′ UTR region of BIRC5 was responsible for the reduction of luciferase activity with sequence specific manner.