In 2005 for example, El-Sheikh et al. used intravital microscopy to examine microvascular thrombosis in the context of colon, mammary, prostate, and lung carcinoma after infusion of a tTF-fused coaguligand consisting of the heparin binding domain of VEGF165 (HBDt, exon 7) that recognizes a trimolecular complex of VEGFR-2 (KDR/Flk-1/CD309), the VEGF165 co-receptor, neuropilin-1 (NRP-1), and the proteoglycan, chondroitin C sulfate (C6S) [55]. This evidence concerns the gene NRP1 and lung carcinoma.