Monoclonal antibodies (e.g., mepolizumab and benralizumab, which block IL-5 and IL-5 receptor -IL5ra-, respectively) can reduce the exacerbation rate and improve the quality of life and are able to spare systemic corticosteroid in eosinophilic severe asthmatic patients with bronchiectasis [6]. The gene discussed is IL5; the disease is bronchiectasis.