In osteosarcoma cell models, KO of ST6GAL1 resulted in decreased malignancy and reduced expression of EMT-associated markers [78]; TGF-β-induced EMT of the mouse epithelial cell line GE11 induced ST6GAL1 up-regulation, while its down-regulation reduced EMT [79]; in pancreatic cancer cells, EGFR-mediated EMT was increased in cells highly expressing ST6GAL1 [80]. The gene discussed is ST6GAL1; the disease is osteosarcoma.