Both sugars of the repeating unit are added by the enzyme products of the genes LARGE1 and LARGE2. In prostate cancer, EMT is induced by hypoglycosylation of α-dystroglycan, which is due to inhibition of LARGE2, by binding to its promoter of the trascriptional repressor ZEB1 and SNAIL [67]. Here, LARGE2 is linked to Familial prostate cancer.