NPM1 and acute myeloid leukemia: Consistent with NPM1 knock-down, the survey of CIGB-300 interactome and quantitative phosphoproteomic analysis corroborated that the CIGB-300 effect in AML could also be mediated by direct impairment of protein kinase CK2 enzymatic activity, in addition to binding to acidic phosphoacceptor in the substrates.