CRP and bacterial infectious disease with sepsis: Second, serum CRP levels were upregulated within 4 to 6 h after sepsis or infection stimulation, doubled after every 8 h, and peaked after 35 to 60 h in patients experiencing bloodstream infections or sepsis [23]; therefore, the high serum CRP levels observed in the nontraumatic OHCA patients indicated that bacteremia occurred prior to resuscitation.