The newest CFTR modulator elexacaftor/tezacaftor/ivacaftor (Trikafta) was approved by the FDA in October 2019 for the treatment of CF in patients 12 years of age or older who have at least one F508del mutation, including both heterozygous for the F508delCFTR mutation and a minimal-function mutation, and homozygous for the F508del mutation. The gene discussed is CFTR; the disease is cystic fibrosis.